SCOPe 2.03: Domain d1xmua_: 1xmu A:

Lineage for d1xmua_ (1xmu A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48550] (28 PDB entries)
   Uniprot Q07343 324-667

8. Domain d1xmua_: 1xmu A: [115562]
   complexed with mg, rof, zn

Details for d1xmua_

PDB Entry: 1xmu, 2.3 Å

PDB Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast

PDB Compounds: (A:) cAMP-specific 3',5'-cyclic phosphodiesterase 4B

SCOPe Domain Sequences for d1xmua_:

Sequence; same for both SEQRES and ATOM records:

>d1xmua_ a.211.1.2 (A:) Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b {Human (Homo sapiens) [TaxId: 9606]}
rfgvntenedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissd
tfitymmtledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaih
dvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtl
rkmvidmvlatdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadls
nptkslelyrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhpl
wetwadlvqpdaqdildtlednrnwyqsmip

Timeline for d1xmua_:

• d1xmua_ first appeared in SCOP 1.71
  
• d1xmua_ appears in SCOPe 2.02
  
• d1xmua_ appears in SCOPe 2.04
  
• d1xmua_ appears in the current release, SCOPe 2.08