SCOPe 2.03: Domain d1xkka_: 1xkk A:

Lineage for d1xkka_ (1xkk A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (38 PDB entries)
   Uniprot P00533 702-1018

8. Domain d1xkka_: 1xkk A: [115409]
   complexed with fmm, po4

Details for d1xkka_

PDB Entry: 1xkk, 2.4 Å

PDB Description: EGFR kinase domain complexed with a quinazoline inhibitor- GW572016

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d1xkka_:

Sequence, based on SEQRES records:

>d1xkka_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d1xkka_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipvkipvaikelrekankeildeayvmasv
dnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyle
drrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmalesilhriythqsdv
wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidads
rpkfreliiefskmardpqrylviqgdermsnfyralmdevvdadeyli

Timeline for d1xkka_:

• d1xkka_ first appeared in SCOP 1.71
  
• d1xkka_ appears in SCOPe 2.02
  
• d1xkka_ appears in SCOPe 2.04
  
• d1xkka_ appears in the current release, SCOPe 2.08