SCOPe 2.06: Domain d1xbtc1: 1xbt C:18-150

Lineage for d1xbtc1 (1xbt C:18-150)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.24: Type II thymidine kinase [117558] (2 proteins)
   N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)

6. Protein Thymidine kinase, TK1, N-terminal domain [117559] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117560] (2 PDB entries)
   Uniprot P04183 18-191

8. Domain d1xbtc1: 1xbt C:18-150 [115084]
   Other proteins in same PDB: d1xbta2, d1xbtb2, d1xbtc2, d1xbtd2, d1xbte2, d1xbtf2, d1xbtg2, d1xbth2
   complexed with mg, ttp, zn

Details for d1xbtc1

PDB Entry: 1xbt, 2.4 Å

PDB Description: Crystal Structure of Human Thymidine Kinase 1

PDB Compounds: (C:) Thymidine kinase, cytosolic

SCOPe Domain Sequences for d1xbtc1:

Sequence, based on SEQRES records:

>d1xbtc1 c.37.1.24 (C:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssfcthdrntmealp
acllrdvaqealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgail
nlvplaesvvklt

Sequence, based on observed residues (ATOM records):

>d1xbtc1 c.37.1.24 (C:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklt

Timeline for d1xbtc1:

• d1xbtc1 first appeared in SCOP 1.71
  
• d1xbtc1 appears in SCOPe 2.05
  
• d1xbtc1 appears in SCOPe 2.07
  
• d1xbtc1 appears in the current release, SCOPe 2.08