Lineage for d1unha_ (1unh A:)

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1433536Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1433537Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1433619Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1434501Protein Cyclin-dependent PK, CDK5 [88857] (1 species)
    CMGC group; CDKs subfamily; serine/threonine kinase
  7. 1434502Species Human (Homo sapiens) [TaxId:9606] [88858] (5 PDB entries)
    Uniprot Q00535
  8. 1434509Domain d1unha_: 1unh A: [113320]
    Other proteins in same PDB: d1unhd_, d1unhe_
    complexed with ixm

Details for d1unha_

PDB Entry: 1unh (more details), 2.35 Å

PDB Description: structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
PDB Compounds: (A:) cyclin-dependent kinase 5

SCOPe Domain Sequences for d1unha_:

Sequence, based on SEQRES records: (download)

>d1unha_ d.144.1.7 (A:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens) [TaxId: 9606]}
qkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkhk
nivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrn
vlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklyst
sidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypm
ypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsd

Sequence, based on observed residues (ATOM records): (download)

>d1unha_ d.144.1.7 (A:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens) [TaxId: 9606]}
qkyeklekiygtvfkaknrheivalkrvrldgvpssalreicllkelkhknivrlhdvlh
sdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrnvlhrdlkpqn
llinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklystsidmwsagci
faelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypmypattslvnv
vpklnatgrdllqnllkcnpvqrisaeealqhpyfsd

SCOPe Domain Coordinates for d1unha_:

Click to download the PDB-style file with coordinates for d1unha_.
(The format of our PDB-style files is described here.)

Timeline for d1unha_: