SCOP 1.71: Domain d1ungb_: 1ung B:

Lineage for d1ungb_ (1ung B:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (60 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK5 [88857] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88858] (4 PDB entries)

8. Domain d1ungb_: 1ung B: [113317]
   Other proteins in same PDB: d1ungd_, d1unge_
   complexed with alh; mutant

Details for d1ungb_

PDB Entry: 1ung, 2.3 Å

PDB Description: structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.

SCOP Domain Sequences for d1ungb_:

Sequence, based on SEQRES records:

>d1ungb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens)}
qkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkhk
nivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrn
vlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklyst
sidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypm
ypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsd

Sequence, based on observed residues (ATOM records):

>d1ungb_ d.144.1.7 (B:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens)}
qkyeklektvfkaivalkrvrldgvpssalreicllkelkhknivrlhdvlhsdkkltlv
fefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrnvlhrdlkpqnllinrnge
lklanfglarafgipvrcysaevvtlwyrppdvlfgaklystsidmwsagcifaelanag
rplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypmypattslvnvvpklnatg
rdllqnllkcnpvqrisaeealqhpyfsd

Timeline for d1ungb_:

• d1ungb_ is new in SCOP 1.71
  
• d1ungb_ appears in SCOP 1.73
  
• d1ungb_ appears in the current release, SCOPe 2.08