SCOPe 2.04: Domain d1um5l1: 1um5 L:2-109

Lineage for d1um5l1 (1um5 L:2-109)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (213 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1um5l1: 1um5 L:2-109 [113304]
   Other proteins in same PDB: d1um5h1, d1um5h2, d1um5l2
   complexed with ss1

Details for d1um5l1

PDB Entry: 1um5, 1.6 Å

PDB Description: Catalytic Antibody 21H3 with alcohol substrate

PDB Compounds: (L:) Antibody 21H3 L chain

SCOPe Domain Sequences for d1um5l1:

Sequence; same for both SEQRES and ATOM records:

>d1um5l1 b.1.1.1 (L:2-109) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
ldiqmtqspsslsaslgervsltcrasqeisgylywlqqkpdgtikrliyagstldsgvp
krfsgsrsgsdysltisslesedfadyyclqyasyprtfgggtkveik

Timeline for d1um5l1:

• d1um5l1 first appeared in SCOP 1.71
  
• d1um5l1 appears in SCOPe 2.03
  
• d1um5l1 appears in SCOPe 2.05
  
• d1um5l1 appears in the current release, SCOPe 2.08