SCOPe 2.06: Domain d1um5h2: 1um5 H:120-219

Lineage for d1um5h2 (1um5 H:120-219)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d1um5h2: 1um5 H:120-219 [113303]
   Other proteins in same PDB: d1um5h1, d1um5l1, d1um5l2
   complexed with ss1

Details for d1um5h2

PDB Entry: 1um5, 1.6 Å

PDB Description: Catalytic Antibody 21H3 with alcohol substrate

PDB Compounds: (H:) Antibody 21H3 H chain

SCOPe Domain Sequences for d1um5h2:

Sequence; same for both SEQRES and ATOM records:

>d1um5h2 b.1.1.2 (H:120-219) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

Timeline for d1um5h2:

• d1um5h2 first appeared in SCOP 1.71
  
• d1um5h2 appears in SCOPe 2.05
  
• d1um5h2 appears in SCOPe 2.07
  
• d1um5h2 appears in the current release, SCOPe 2.08