SCOPe 2.01: Domain d1u8ha2: 1u8h A:108-214

Lineage for d1u8ha2 (1u8h A:108-214)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (132 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1u8ha2: 1u8h A:108-214 [113129]
   Other proteins in same PDB: d1u8ha1, d1u8hb1, d1u8hb2

Details for d1u8ha2

PDB Entry: 1u8h, 2.1 Å

PDB Description: Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ALDKWAS

PDB Compounds: (A:) antibody 2f5 (light chain)

SCOPe Domain Sequences for d1u8ha2:

Sequence; same for both SEQRES and ATOM records:

>d1u8ha2 b.1.1.2 (A:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyecevthqglsspvtksfnrgec

Timeline for d1u8ha2:

• d1u8ha2 first appeared in SCOP 1.71
  
• d1u8ha2 appears in SCOP 1.75
  
• d1u8ha2 appears in SCOPe 2.02
  
• d1u8ha2 appears in the current release, SCOPe 2.08