SCOP 1.71: Domain d1tl1b1: 1tl1 B:7-427

Lineage for d1tl1b1 (1tl1 B:7-427)

1. Root: SCOP 1.71

2. Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (83 PDB entries)

8. Domain d1tl1b1: 1tl1 B:7-427 [112495]
   Other proteins in same PDB: d1tl1a1
   complexed with h18, po4

Details for d1tl1b1

PDB Entry: 1tl1, 2.9 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase in complex with gw451211

SCOP Domain Sequences for d1tl1b1:

Sequence, based on SEQRES records:

>d1tl1b1 e.8.1.2 (B:7-427) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
y

Sequence, based on observed residues (ATOM records):

>d1tl1b1 e.8.1.2 (B:7-427) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikst
kwrklvdfrelnkrtqdfwphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsi
nnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsdlei
gqhrtkieelrqhllrwglppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgkln
wasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdl
iaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpkfk
lpiqketwetwwteywqatwipewefvntpplvklwy

Timeline for d1tl1b1:

• d1tl1b1 is new in SCOP 1.71
  
• d1tl1b1 appears in SCOP 1.73
  
• d1tl1b1 appears in the current release, SCOPe 2.08