SCOPe 2.06: Domain d1tjgl2: 1tjg L:108-214

Lineage for d1tjgl2 (1tjg L:108-214)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d1tjgl2: 1tjg L:108-214 [112449]
   Other proteins in same PDB: d1tjgh1, d1tjgh2, d1tjgl1
   complexed with edo, ipa

Details for d1tjgl2

PDB Entry: 1tjg, 2 Å

PDB Description: Crystal Structure of the broadly neutralizing anti-HIV-1 antibody 2F5 in complex with a gp41 7mer epitope

PDB Compounds: (L:) FAB 2F5 Light Chain

SCOPe Domain Sequences for d1tjgl2:

Sequence; same for both SEQRES and ATOM records:

>d1tjgl2 b.1.1.2 (L:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d1tjgl2:

• d1tjgl2 first appeared in SCOP 1.71
  
• d1tjgl2 appears in SCOPe 2.05
  
• d1tjgl2 appears in SCOPe 2.07
  
• d1tjgl2 appears in the current release, SCOPe 2.08