SCOPe 2.05: Domain d1vjya_: 1vjy A:

Lineage for d1vjya_ (1vjy A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (16 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d1vjya_: 1vjy A: [108633]
   complexed with 460

Details for d1vjya_

PDB Entry: 1vjy, 2 Å

PDB Description: Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor

PDB Compounds: (A:) tgf-beta receptor type I

SCOPe Domain Sequences for d1vjya_:

Sequence, based on SEQRES records:

>d1vjya_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkryma
pevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsvee
mrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqqeg
ikm

Sequence, based on observed residues (ATOM records):

>d1vjya_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
iartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhenil
gfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhmei
vgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidirvgtkrymapevl
ddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsveemrkv
vceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqqegikm

Timeline for d1vjya_:

• d1vjya_ first appeared in SCOP 1.69
  
• d1vjya_ appears in SCOPe 2.04
  
• d1vjya_ appears in SCOPe 2.06
  
• d1vjya_ appears in the current release, SCOPe 2.08