SCOPe 2.03: Domain d1u46b_: 1u46 B:

Lineage for d1u46b_ (1u46 B:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Activated CDC42 kinase 1, ACK1 [111200] (1 species)
   PTK group; Tck subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [111201] (7 PDB entries)
   Uniprot Q07912 117-389

8. Domain d1u46b_: 1u46 B: [107657]
   complexed with cl

Details for d1u46b_

PDB Entry: 1u46, 2 Å

PDB Description: Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1

PDB Compounds: (B:) Activated CDC42 kinase 1

SCOPe Domain Sequences for d1u46b_:

Sequence, based on SEQRES records:

>d1u46b_ d.144.1.7 (B:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklgdgsfgvvrrgewdapsgktvsvavkclkpdvlsqpeamddfir
evnamhsldhrnlirlygvvltppmkmvtelaplgslldrlrkhqghfllgtlsryavqv
aegmgyleskrfihrdlaarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfaw
capeslktrtfshasdtwmfgvtlwemftygqepwiglngsqilhkidkegerlprpedc
pqdiynvmvqcwahkpedrptfvalrdflleaqp

Sequence, based on observed residues (ATOM records):

>d1u46b_ d.144.1.7 (B:) Activated CDC42 kinase 1, ACK1 {Human (Homo sapiens) [TaxId: 9606]}
ltcligekdlrlleklggvvrrgewdapsgktvsvavkcmddfirevnamhsldhrnlir
lygvvltppmkmvtelaplgslldrlrkhqgllgtlsryavqvaegmgyleskrfihrdl
aarnlllatrdlvkigdfglmralpqnddhyvmqehrkvpfawcapeslktrtfshasdt
wmfgvtlwemftygqepwiglngsqilhkidkegerlprpedcpqdiynvmvqcwahkpe
drptfvalrdflleaqp

Timeline for d1u46b_:

• d1u46b_ first appeared in SCOP 1.69
  
• d1u46b_ appears in SCOPe 2.02
  
• d1u46b_ appears in SCOPe 2.04
  
• d1u46b_ appears in the current release, SCOPe 2.08