SCOPe 2.04: Domain d1tzha1: 1tzh A:1-107

Lineage for d1tzha1 (1tzh A:1-107)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Engineered (including hybrid species) [88533] (61 PDB entries)
   SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # Humanized antibody ! SQ NA # humanized antibody ! SQ NA # engineered antibody

8. Domain d1tzha1: 1tzh A:1-107 [107477]
   Other proteins in same PDB: d1tzha2, d1tzhb1, d1tzhb2, d1tzhh1, d1tzhh2, d1tzhl2, d1tzhv_, d1tzhw_

Details for d1tzha1

PDB Entry: 1tzh, 2.6 Å

PDB Description: Crystal Structure of the Fab YADS1 Complexed with h-VEGF

PDB Compounds: (A:) Fab YADS1 Light Chain

SCOPe Domain Sequences for d1tzha1:

Sequence; same for both SEQRES and ATOM records:

>d1tzha1 b.1.1.1 (A:1-107) Immunoglobulin light chain kappa variable domain, VL-kappa {Engineered (including hybrid species)}
diqmtqspsslsasvgdrvtitcrasqasyssvawyqqkpgkapklliyaasylysgvps
rfsgsgsgtdftltisslqpedfatyycqssaspatfgqgtkveik

Timeline for d1tzha1:

• d1tzha1 first appeared in SCOP 1.69
  
• d1tzha1 appears in SCOPe 2.03
  
• d1tzha1 appears in SCOPe 2.05
  
• d1tzha1 appears in the current release, SCOPe 2.08