SCOPe 2.08: Domain d1tt5c_: 1tt5 C:

Lineage for d1tt5c_ (1tt5 C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

7. Species Human (Homo sapiens) [TaxId:9606] [89767] (10 PDB entries)
   Uniprot Q13564

8. Domain d1tt5c_: 1tt5 C: [107293]
   Other proteins in same PDB: d1tt5b1, d1tt5b2, d1tt5d_
   complexed with zn
   has additional subdomain(s) that are not in the common domain

Details for d1tt5c_

PDB Entry: 1tt5, 2.6 Å

PDB Description: structure of appbp1-uba3-ubc12n26: a unique e1-e2 interaction required for optimal conjugation of the ubiquitin-like protein nedd8

PDB Compounds: (C:) amyloid protein-binding protein 1

SCOPe Domain Sequences for d1tt5c_:

Sequence, based on SEQRES records:

>d1tt5c_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
llkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvs
gedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvv
vatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrld
kpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrdl
irqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaral
kefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqa
pesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlra
vdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaeph
tiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Sequence, based on observed residues (ATOM records):

>d1tt5c_ c.111.1.2 (C:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
llkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqvs
gedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftvv
vatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrld
kpfpelrehfqsyhtpwiviiakylaqwysetngripktykekedfrdlirqgilkpede
enfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaralkefvakegqgn
lpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqapesisekelkl
lcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlravdrfhkqqgry
pgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaephtiaaflggaaa
qevikiitkqfvifnntyiysgmsqtsatfql

Timeline for d1tt5c_:

• d1tt5c_ first appeared in SCOP 1.69
  
• d1tt5c_ appears in SCOPe 2.07