SCOPe 2.06: Domain d1t94b2: 1t94 B:75-407

Lineage for d1t94b2 (1t94 B:75-407)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.7: Lesion bypass DNA polymerase (Y-family), catalytic domain [100888] (5 proteins)
   contains a distinct 'fingers' domain possibly related to the C-terminal subdomain of hypothetical protein Ta1206 (1qw2)

6. Protein DNA polymerase kappa [111297] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111298] (1 PDB entry)
   Uniprot Q9UBT6 71-517

8. Domain d1t94b2: 1t94 B:75-407 [106704]
   Other proteins in same PDB: d1t94a1, d1t94b1

Details for d1t94b2

PDB Entry: 1t94, 2.4 Å

PDB Description: crystal structure of the catalytic core of human dna polymerase kappa

PDB Compounds: (B:) polymerase (DNA directed) kappa

SCOPe Domain Sequences for d1t94b2:

Sequence, based on SEQRES records:

>d1t94b2 e.8.1.7 (B:75-407) DNA polymerase kappa {Human (Homo sapiens) [TaxId: 9606]}
tsqqlrkaqlqvdrfameleqsrnlsntivhidmdafyaavemrdnpelkdkpiavgsms
mlstsnyharrfgvraampgfiakrlcpqliivppnfdkyravskevkeiladydpnfma
msldeaylnitkhleerqnwpedkrryfikmgssvendnpgkevnklsehersispllfe
espsdvqppgdpfqvnfeeqnnpqilqnsvvfgtsaqevvkeirfrieqkttltasagia
pntmlakvcsdknkpngqyqilpnrqavmdfikdlpirkvsgigkvtekmlkalgiitct
elyqqrallsllfsetswhyflhislglgsthl

Sequence, based on observed residues (ATOM records):

>d1t94b2 e.8.1.7 (B:75-407) DNA polymerase kappa {Human (Homo sapiens) [TaxId: 9606]}
tsqqlrkaqlqvdrfameleqsrnlsntivhidmdafyaavemrdnpelkdkpiavgsms
mlstsnyharrfgvraampgfiakrlcpqliivppnfdkyravskevkeiladydpnfma
msldeaylnitkhleerqnwpedkrryfikqnsvvfgtsaqevvkeirfrieqkttltas
agiapntmlakvcsdknkpngqyqilpnrqavmdfikdlpirkvsgigkvtekmlkalgi
itctelyqqrallsllfsetswhyflhislglgsthl

Timeline for d1t94b2:

• d1t94b2 first appeared in SCOP 1.69
  
• d1t94b2 appears in SCOPe 2.05
  
• d1t94b2 appears in SCOPe 2.07
  
• d1t94b2 appears in the current release, SCOPe 2.08