SCOPe 2.07: Domain d1t8ua1: 1t8u A:139-406

Lineage for d1t8ua1 (1t8u A:139-406)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.5: PAPS sulfotransferase [52575] (15 proteins)
   Pfam PF00685
   similar to the nucleotide/nucleoside kinases but transfer sulphate group

6. Protein Heparan sulfate glucosamine 3-O-sulfotransferase 3 [110532] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110533] (2 PDB entries)
   Uniprot Q9Y663 139-406 # isoform 3A1; 100% sequence identity to isoform 3B1 domain (Uniprot Q9Y662 133-390)

8. Domain d1t8ua1: 1t8u A:139-406 [106687]
   Other proteins in same PDB: d1t8ua2, d1t8ub2
   complexed with a3p, ids, na, sgn, so4, uap

Details for d1t8ua1

PDB Entry: 1t8u, 1.95 Å

PDB Description: crystal structure of human 3-o-sulfotransferase-3 with bound pap and tetrasaccharide substrate

PDB Compounds: (A:) heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1

SCOPe Domain Sequences for d1t8ua1:

Sequence, based on SEQRES records:

>d1t8ua1 c.37.1.5 (A:139-406) Heparan sulfate glucosamine 3-O-sulfotransferase 3 {Human (Homo sapiens) [TaxId: 9606]}
gtlallldegskqlpqaiiigvkkggtralleflrvhpdvravgaephffdrsydkglaw
yrdlmprtldgqitmektpsyfvtreaparisamskdtklivvvrdpvtraisdytqtls
krpdiptfesltfknrtaglidtswsaiqigiyakhlehwlrhfpirqmlfvsgerlisd
pagelgrvqdflglkriitdkhfyfnktkgfpclkkaegssrphclgktkgrthpeidre
vvrrlrefyrpfnlkfyqmtghdfgwdg

Sequence, based on observed residues (ATOM records):

>d1t8ua1 c.37.1.5 (A:139-406) Heparan sulfate glucosamine 3-O-sulfotransferase 3 {Human (Homo sapiens) [TaxId: 9606]}
gtlallldegskqlpqaiiigvkkggtralleflrvhpdvravgaephffdrsydkglaw
yrdlmprtldgqitmektpsyfvtreaparisamskdtklivvvrdpvtraisdytqtls
krpdiptfesltfknglidtswsaiqigiyakhlehwlrhfpirqmlfvsgerlisdpag
elgrvqdflglkriitdkhfyfnktkgfpclkkaegssrphclgktkgrthpeidrevvr
rlrefyrpfnlkfyqmtghdfgwdg

Timeline for d1t8ua1:

• d1t8ua1 first appeared in SCOP 1.69, called d1t8ua_
  
• d1t8ua1 appears in SCOPe 2.06
  
• d1t8ua1 appears in the current release, SCOPe 2.08