SCOP 1.71: Domain d1t45a_: 1t45 A:

Lineage for d1t45a_ (1t45 A:)

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (60 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-KIT receptor [103296] (1 species)
   PTK group; PDGFR/VEGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103297] (3 PDB entries)

8. Domain d1t45a_: 1t45 A: [106396]

Details for d1t45a_

PDB Entry: 1t45, 1.9 Å

PDB Description: structural basis for the autoinhibition and sti-571 inhibition of c- kit tyrosine kinase

SCOP Domain Sequences for d1t45a_:

Sequence; same for both SEQRES and ATOM records:

>d1t45a_ d.144.1.7 (A:) c-KIT receptor {Human (Homo sapiens)}
ylqkpmyevqwkvveeingnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taygliksdaamtvavkmlkpsahlterealmselkvlsylgnhmnivnllgactiggpt
lviteyccygdllnflrrkrdsficsktspaimeddelaldledllsfsyqvakgmafla
skncihrdlaarnillthgritkicdfglardikndsnyvvkgnarlpvkwmapesifnc
vytfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmlspehapaemydimk
tcwdadplkrptfkqivqliekqisestnhi

Timeline for d1t45a_:

• d1t45a_ first appeared in SCOP 1.69
  
• d1t45a_ appears in SCOP 1.73
  
• d1t45a_ appears in the current release, SCOPe 2.08