SCOP 1.73: Domain d1sy6h1: 1sy6 H:1-119

Lineage for d1sy6h1 (1sy6 H:1-119)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (29 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (148 PDB entries)

8. Domain d1sy6h1: 1sy6 H:1-119 [106113]
   Other proteins in same PDB: d1sy6a1, d1sy6a2, d1sy6h2, d1sy6l1, d1sy6l2
   MQ P01750 P01863 # natural chimera

Details for d1sy6h1

PDB Entry: 1sy6, 2.1 Å

PDB Description: crystal structure of cd3gammaepsilon heterodimer in complex with okt3 fab fragment

PDB Compounds: (H:) OKT3 Fab heavy chain

SCOP Domain Sequences for d1sy6h1:

Sequence; same for both SEQRES and ATOM records:

>d1sy6h1 b.1.1.1 (H:1-119) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}
qvqlqqsgaelarpgasvkmsckasgytftrytmhwvkqrpgqglewigyinpsrgytny
nqkfkdkatlttdkssstaymqlssltsedsavyycaryyddhycldywgqgttltvss

Timeline for d1sy6h1:

• d1sy6h1 first appeared in SCOP 1.69
  
• d1sy6h1 appears in SCOP 1.71
  
• d1sy6h1 appears in SCOP 1.75
  
• d1sy6h1 appears in the current release, SCOPe 2.08