SCOPe 2.05: Domain d1siqa2: 1siq A:3-238

Lineage for d1siqa2 (1siq A:3-238)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (3 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (10 proteins)

6. Protein Glutaryl-CoA dehydrogenase GCDH [111293] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [111294] (3 PDB entries)
   Uniprot Q92947

8. Domain d1siqa2: 1siq A:3-238 [105586]
   Other proteins in same PDB: d1siqa1
   complexed with fad

Details for d1siqa2

PDB Entry: 1siq, 2.1 Å

PDB Description: The Crystal Structure and Mechanism of Human Glutaryl-CoA Dehydrogenase

PDB Compounds: (A:) Glutaryl-CoA dehydrogenase

SCOPe Domain Sequences for d1siqa2:

Sequence; same for both SEQRES and ATOM records:

>d1siqa2 e.6.1.1 (A:3-238) Glutaryl-CoA dehydrogenase GCDH {Human (Homo sapiens) [TaxId: 9606]}
efdwqdplvleeqlttdeilirdtfrtycqerlmprillanrnevfhreiisemgelgvl
gptikgygcagvssvaygllarelervdsgyrsamsvqsslvmhpiyaygseeqrqkylp
qlakgellgcfgltepnsgsdpssmetrahynssnksytlngtktwitnspmadlfvvwa
rcedgcirgfllekgmrglsapriqgkfslrasatgmiimdgvevpeenvlpgass

Timeline for d1siqa2:

• d1siqa2 first appeared in SCOP 1.69
  
• d1siqa2 appears in SCOPe 2.04
  
• d1siqa2 appears in SCOPe 2.06
  
• d1siqa2 appears in the current release, SCOPe 2.08