SCOP 1.73: Domain d1s3kl1: 1s3k L:1-112

Lineage for d1s3kl1 (1s3k L:1-112)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (29 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (127 PDB entries)

8. Domain d1s3kl1: 1s3k L:1-112 [105239]
   Other proteins in same PDB: d1s3kh2, d1s3kl2
   MQ NA # artificial chimera
   complexed with fuc, gal, gol, nag

Details for d1s3kl1

PDB Entry: 1s3k, 1.9 Å

PDB Description: crystal structure of a humanized fab (hu3s193) in complex with the lewis y tetrasaccharide

PDB Compounds: (L:) HU3S193 Fab fragment, light chain

SCOP Domain Sequences for d1s3kl1:

Sequence; same for both SEQRES and ATOM records:

>d1s3kl1 b.1.1.1 (L:1-112) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 1.1 [TaxId: 10090]}
diqmtqspsslsasvgdrvtitcrssqrivhsngntylewyqqtpgkapklliykvsnrf
sgvpsrfsgsgsgtdftftisslqpediatyycfqgshvpftfgqgtklqit

Timeline for d1s3kl1:

• d1s3kl1 first appeared in SCOP 1.69
  
• d1s3kl1 appears in SCOP 1.71
  
• d1s3kl1 appears in SCOP 1.75
  
• d1s3kl1 appears in the current release, SCOPe 2.08