Lineage for d1s3kh2 (1s3k H:120-219)

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1510240Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1510241Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1513476Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)
  6. 1515183Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 1515187Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 1515492Domain d1s3kh2: 1s3k H:120-219 [105238]
    Other proteins in same PDB: d1s3kh1, d1s3kl1, d1s3kl2
    MQ NA P01857 # artificial chimera
    complexed with gol

Details for d1s3kh2

PDB Entry: 1s3k (more details), 1.9 Å

PDB Description: crystal structure of a humanized fab (hu3s193) in complex with the lewis y tetrasaccharide
PDB Compounds: (H:) HU3S193 Fab fragment, heavy chain

SCOPe Domain Sequences for d1s3kh2:

Sequence, based on SEQRES records: (download)

>d1s3kh2 b.1.1.2 (H:120-219) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpqpvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

Sequence, based on observed residues (ATOM records): (download)

>d1s3kh2 b.1.1.2 (H:120-219) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapgtaalgclvkdyfpqpvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkvep

SCOPe Domain Coordinates for d1s3kh2:

Click to download the PDB-style file with coordinates for d1s3kh2.
(The format of our PDB-style files is described here.)

Timeline for d1s3kh2:

View in 3D
Domains from same chain:
(mouse over for more information)
d1s3kh1