SCOPe 2.05: Domain d1s1wb1: 1s1w B:5-428

Lineage for d1s1wb1 (1s1w B:5-428)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (3 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (153 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1s1wb1: 1s1w B:5-428 [105216]
   Other proteins in same PDB: d1s1wa1
   complexed with uc1; mutant

Details for d1s1wb1

PDB Entry: 1s1w, 2.7 Å

PDB Description: crystal structure of v106a mutant hiv-1 reverse transcriptase in complex with uc-781

PDB Compounds: (B:) reverse transcriptase

SCOPe Domain Sequences for d1s1wb1:

Sequence, based on SEQRES records:

>d1s1wb1 e.8.1.2 (B:5-428) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksatvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpi
vlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelela
enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtnd
vkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvk
lwyq

Sequence, based on observed residues (ATOM records):

>d1s1wb1 e.8.1.2 (B:5-428) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwlgiphpaglkkkksatvldvgdayfsvpldedfrky
taftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddl
yvgsdleigqhrtkieelrqhllrwgppflwmgyelhpdkwtvqpivlpekdswtvndiq
klvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvy
ydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyatndvkqlteavqkittesiviwg
ktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq

Timeline for d1s1wb1:

• d1s1wb1 first appeared in SCOP 1.69
  
• d1s1wb1 appears in SCOPe 2.04
  
• d1s1wb1 appears in SCOPe 2.06
  
• d1s1wb1 appears in the current release, SCOPe 2.08