SCOPe 2.06: Domain d1pu2a1: 1pu2 A:1-133,A:358-371

Lineage for d1pu2a1 (1pu2 A:1-133,A:358-371)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
   family members also share a common alpha+beta fold in C-terminal domain

6. Protein Aspartate beta-semialdehyde dehydrogenase [51813] (4 species)

7. Species Haemophilus influenzae [TaxId:727] [102159] (12 PDB entries)
   Uniprot P44801

8. Domain d1pu2a1: 1pu2 A:1-133,A:358-371 [104308]
   Other proteins in same PDB: d1pu2a2
   mutant

Details for d1pu2a1

PDB Entry: 1pu2, 2.06 Å

PDB Description: crystal structure of the k246r mutant of aspartate semialdehyde dehydrogenase from haemophilus influenzae

PDB Compounds: (A:) aspartate-semialdehyde dehydrogenase

SCOPe Domain Sequences for d1pu2a1:

Sequence, based on SEQRES records:

>d1pu2a1 c.2.1.3 (A:1-133,A:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqagqkapvfggkdagdlksafd
ieelkkldiivtcqggdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhvi
seglkkgiktfvgXaaepvrrilkqlva

Sequence, based on observed residues (ATOM records):

>d1pu2a1 c.2.1.3 (A:1-133,A:358-371) Aspartate beta-semialdehyde dehydrogenase {Haemophilus influenzae [TaxId: 727]}
mknvgfigwrgmvgsvlmdrmsqendfenlnpvffttsqalksafdieelkkldiivtcq
ggdytnevypklkatgwdgywvdaasalrmkddaiivldpvnqhviseglkkgiktfvgX
aaepvrrilkqlva

Timeline for d1pu2a1:

• d1pu2a1 first appeared in SCOP 1.69
  
• d1pu2a1 appears in SCOPe 2.05
  
• d1pu2a1 appears in SCOPe 2.07
  
• d1pu2a1 appears in the current release, SCOPe 2.08