SCOP 1.75: Family d.110.7.1: Roadblock/LC7 domain

Lineage for Family d.110.7.1: Roadblock/LC7 domain

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.110: Profilin-like [55769] (10 superfamilies)
   core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha

4. Superfamily d.110.7: Roadblock/LC7 domain [103196] (1 family)
   alpha-beta(2)-alpha-beta(3)-alpha; structurally most similar to the SNARE-like superfamily with a circular permutation of the terminal helices

5. Family d.110.7.1: Roadblock/LC7 domain [103197] (4 proteins)
   Pfam PF03259

Proteins:

1. Dynein light chain 2A, cytoplasmic [118074] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [118075] (4 PDB entries)
      Uniprot Q9NP97

   2. Species Mouse (Mus musculus) [TaxId:10090] [160682] (1 PDB entry)
      Uniprot P62627 1-95

2. Giding protein MglB [103198] (1 species)

   • Species Thermus thermophilus [TaxId:274] [103199] (1 PDB entry)

3. Late endosomal/lysosomal Mp1 interacting protein p14 [111123] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [111124] (5 PDB entries)
     Uniprot Q9JHS3

4. MEK binding partner 1, MP1 [111120] (2 species)
   remote homolog that forms the characteristic complex structures with other members

   1. Species Human (Homo sapiens) [TaxId:9606] [111121] (2 PDB entries)
      Uniprot Q9UHA4

   2. Species Mouse (Mus musculus) [TaxId:10090] [111122] (2 PDB entries)
      Uniprot O88653

More info for Family d.110.7.1: Roadblock/LC7 domain

Timeline for Family d.110.7.1: Roadblock/LC7 domain:

• Family d.110.7.1: Roadblock/LC7 domain first appeared in SCOP 1.67
  
• Family d.110.7.1: Roadblock/LC7 domain appears in SCOP 1.73
  
• Family d.110.7.1: Roadblock/LC7 domain appears in SCOPe 2.01
  
• Family d.110.7.1: Roadblock/LC7 domain appears in the current release, SCOPe 2.08