SCOPe 2.01: Domain d1v7mm2: 1v7m M:108-212

Lineage for d1v7mm2 (1v7m M:108-212)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (5 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [88567] (318 PDB entries)
   Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region

8. Domain d1v7mm2: 1v7m M:108-212 [100457]
   Other proteins in same PDB: d1v7mh1, d1v7mh2, d1v7mi1, d1v7mi2, d1v7ml1, d1v7mm1, d1v7mv_, d1v7mx_
   part of anti-trombopoetin Fab tn1

Details for d1v7mm2

PDB Entry: 1v7m, 2.51 Å

PDB Description: Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

PDB Compounds: (M:) Monoclonal TN1 Fab Light Chain

SCOPe Domain Sequences for d1v7mm2:

Sequence; same for both SEQRES and ATOM records:

>d1v7mm2 b.1.1.2 (M:108-212) Immunoglobulin light chain kappa constant domain, CL-kappa {Mouse (Mus musculus) [TaxId: 10090]}
adaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqds
kdstysmsstltltkdeyerhnsytceathktstspivksfnrne

Timeline for d1v7mm2:

• d1v7mm2 first appeared in SCOP 1.67
  
• d1v7mm2 appears in SCOP 1.75
  
• d1v7mm2 appears in SCOPe 2.02
  
• d1v7mm2 appears in the current release, SCOPe 2.08