SCOPe 2.02: Domain d1v7mh1: 1v7m H:1-116

Lineage for d1v7mh1 (1v7m H:1-116)

1. Root: SCOPe 2.02

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (46 PDB entries)
   Uniprot P01796 # ! HV27_MOUSE Ig heavy chain V-III region A4

8. Domain d1v7mh1: 1v7m H:1-116 [100450]
   Other proteins in same PDB: d1v7mh2, d1v7mi2, d1v7ml1, d1v7ml2, d1v7mm1, d1v7mm2, d1v7mv_, d1v7mx_
   part of anti-trombopoetin Fab tn1

Details for d1v7mh1

PDB Entry: 1v7m, 2.51 Å

PDB Description: Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

PDB Compounds: (H:) Monoclonal TN1 Fab Heavy Chain

SCOPe Domain Sequences for d1v7mh1:

Sequence; same for both SEQRES and ATOM records:

>d1v7mh1 b.1.1.1 (H:1-116) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 1 [TaxId: 10090]}
evkleesggglvqpggsmklscaasgftfsdawmdwvrqspekglewvaeirskvnnhai
hyaesvkgrftvsrddskssvylqmnslraedtgiyycsgwsflywgqgtlvtvsa

Timeline for d1v7mh1:

• d1v7mh1 first appeared in SCOP 1.67
  
• d1v7mh1 appears in SCOPe 2.01
  
• d1v7mh1 appears in SCOPe 2.03
  
• d1v7mh1 appears in the current release, SCOPe 2.08