Lineage for d1uwev2 (1uwe V:114-216)

  1. Root: SCOPe 2.04
  2. 1510239Class b: All beta proteins [48724] (176 folds)
  3. 1510240Fold b.1: Immunoglobulin-like beta-sandwich [48725] (31 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1510241Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1513476Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)
  6. 1515183Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
  7. 1515187Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
    including humanized antibodies (chimeric proteins with human constant domains)
    Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
  8. 1515408Domain d1uwev2: 1uwe V:114-216 [100110]
    Other proteins in same PDB: d1uweh1, d1uwel1, d1uwel2, d1uweu1, d1uweu2, d1uwev1, d1uwex1, d1uwex2, d1uwey1
    part of catalytic Fab 14d9

Details for d1uwev2

PDB Entry: 1uwe (more details), 2.67 Å

PDB Description: molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14d9
PDB Compounds: (V:) antibody 14d9

SCOPe Domain Sequences for d1uwev2:

Sequence; same for both SEQRES and ATOM records: (download)

>d1uwev2 b.1.1.2 (V:114-216) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntavdkavepksc

SCOPe Domain Coordinates for d1uwev2:

Click to download the PDB-style file with coordinates for d1uwev2.
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Timeline for d1uwev2: