SCOPe 2.01: Domain d1uu7a_: 1uu7 A:

Lineage for d1uu7a_ (1uu7 A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (17 PDB entries)
   Uniprot O15530 75-363

8. Domain d1uu7a_: 1uu7 A: [100000]
   complexed with bi2, gol, so4

Details for d1uu7a_

PDB Entry: 1uu7, 1.9 Å

PDB Description: structure of human pdk1 kinase domain in complex with bim-2

PDB Compounds: (A:) 3-phosphoinositide dependent protein kinase-1

SCOPe Domain Sequences for d1uu7a_:

Sequence, based on SEQRES records:

>d1uu7a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspe
llteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardl
vekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d1uu7a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlspransfvgtaqyvspelltek
sackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekll
vldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d1uu7a_:

• d1uu7a_ first appeared in SCOP 1.67
  
• d1uu7a_ appears in SCOP 1.75
  
• d1uu7a_ appears in SCOPe 2.02
  
• d1uu7a_ appears in the current release, SCOPe 2.08