Lineage for d4hvga_ (4hvg A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2546221Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2546222Protein automated matches [190417] (26 species)
    not a true protein
  7. 2546365Species Human (Homo sapiens) [TaxId:9606] [187294] (936 PDB entries)
  8. 2547120Domain d4hvga_: 4hvg A: [222753]
    automated match to d3q32b_
    complexed with 19q

Details for d4hvga_

PDB Entry: 4hvg (more details), 2.75 Å

PDB Description: JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-2-hydroxy-1,2-dimethyl-propyl)-amide
PDB Compounds: (A:) Tyrosine-protein kinase JAK3

SCOPe Domain Sequences for d4hvga_:

Sequence, based on SEQRES records: (download)

>d4hvga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqi
ckgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifw
yapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrllel
leegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

Sequence, based on observed residues (ATOM records): (download)

>d4hvga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiq
ilkalhsdfivkyrgvsygplrlvmeylpsgclrdflqrhrarldasrlllyssqickgm
eylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyape
slsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmvpalsrllelleegqrlpa
ppacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsr

SCOPe Domain Coordinates for d4hvga_:

Click to download the PDB-style file with coordinates for d4hvga_.
(The format of our PDB-style files is described here.)

Timeline for d4hvga_: