Lineage for d4gpqa2 (4gpq A:231-589)
- Root: SCOPe 2.08
Class a: All alpha proteins [46456] (290 folds) 
Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix
Superfamily a.118.8: TPR-like [48452] (11 families) 
Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (21 proteins)
this is a repeat family; one repeat unit is 1zb1 A:166-231 found in domainProtein Menin C-terminal domain [310725] (2 species) Species Human (Homo sapiens) [TaxId:9606] [310974] (33 PDB entries) 
Domain d4gpqa2: 4gpq A:231-589 [307461]
Other proteins in same PDB: d4gpqa1
automated match to d3u85a2
complexed with epe, peg, pg4
has additional insertions and/or extensions that are not grouped together
Details for d4gpqa2
PDB Entry: 4gpq (more details), 1.46 Å
PDB Description: Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
PDB Compounds: (A:) MeninSCOPe Domain Sequences for d4gpqa2:
Sequence, based on SEQRES records: (download)
>d4gpqa2 a.118.8.1 (A:231-589) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpapaaspppegpvltfqsekmk
gmkellvatkinssaiklqltaqsqvqmkk
Sequence, based on observed residues (ATOM records): (download)
>d4gpqa2 a.118.8.1 (A:231-589) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsgpvltfqsekmkgmkellvatki
nssaiklqltaqsqvqmkk
SCOPe Domain Coordinates for d4gpqa2:
Click to download the PDB-style file with coordinates for d4gpqa2.
(The format of our PDB-style files is described here.)
(The format of our PDB-style files is described here.)
Timeline for d4gpqa2:
- d4gpqa2 first appeared in SCOPe 2.06
- d4gpqa2 appears in SCOPe 2.07
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