Lineage for d3siea_ (3sie A:)
- Root: SCOPe 2.06
Class a: All alpha proteins [46456] (289 folds) 
Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
multihelical; consists of two different alpha-helical bundlesSuperfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) 
Family a.211.1.2: PDEase [48548] (7 proteins)
Pfam PF00233; multihelical; can be divided into three subdomains
Protein automated matches [190370] (1 species)
not a true proteinSpecies Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries) 
Domain d3siea_: 3sie A: [193656]
automated match to d3b2ra_
complexed with 5bo
Details for d3siea_
PDB Entry: 3sie (more details), 1.93 Å
PDB Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesteraseSCOPe Domain Sequences for d3siea_:
Sequence, based on SEQRES records: (download)
>d3siea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
relqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlcr
wilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdldh
rgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkiik
qailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqr
iaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvse
dcfplldgcrknrqkwqalaeqq
Sequence, based on observed residues (ATOM records): (download)
>d3siea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
relqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlcr
wilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdldh
imehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlalyikrrgeffeli
rknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkeptd
lmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq
SCOPe Domain Coordinates for d3siea_:
Click to download the PDB-style file with coordinates for d3siea_.
(The format of our PDB-style files is described here.)
(The format of our PDB-style files is described here.)
Timeline for d3siea_:
- d3siea_ first appeared in SCOPe 2.02
- d3siea_ appears in SCOPe 2.05
- d3siea_ appears in SCOPe 2.07
- d3siea_ appears in the current release, SCOPe 2.08
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