Lineage for d3ed7a_ (3ed7 A:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2972108Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2972109Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2972110Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 2972567Protein automated matches [190469] (17 species)
    not a true protein
  7. 2972632Species Human (Homo sapiens) [TaxId:9606] [189245] (10 PDB entries)
  8. 2972633Domain d3ed7a_: 3ed7 A: [174856]
    automated match to d1hvya_
    complexed with so4

Details for d3ed7a_

PDB Entry: 3ed7 (more details), 1.56 Å

PDB Description: replacement of val3 in human thymidylate synthase affects its kinetic properties and intracellular stability
PDB Compounds: (A:) Thymidylate synthase

SCOPe Domain Sequences for d3ed7a_:

Sequence, based on SEQRES records: (download)

>d3ed7a_ d.117.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvf
wkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwr
hfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcq
fyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiyln
hieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

Sequence, based on observed residues (ATOM records): (download)

>d3ed7a_ d.117.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvf
wkgvleellwfikgstnakelsswdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm

SCOPe Domain Coordinates for d3ed7a_:

Click to download the PDB-style file with coordinates for d3ed7a_.
(The format of our PDB-style files is described here.)

Timeline for d3ed7a_: