Lineage for d2f5ah1 (2f5a H:1-132)
- Root: SCOPe 2.03
Class b: All beta proteins [48724] (174 folds) 
Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
sandwich; 7 strands in 2 sheets; greek-key
some members of the fold have additional strands
Superfamily b.1.1: Immunoglobulin [48726] (5 families) 
Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins) 
Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
Species Engineered (including hybrid species) [88562] (68 PDB entries)
SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody
Domain d2f5ah1: 2f5a H:1-132 [88502]
Other proteins in same PDB: d2f5ah2, d2f5al1, d2f5al2
part of humanized HIV-1 neutralizing Fab 2F5
Details for d2f5ah1
PDB Entry: 2f5a (more details), 2.05 Å
PDB Description: crystal structure of fab' from the hiv-1 neutralizing antibody 2f5
PDB Compounds: (H:) protein (antibody 2f5 (heavy chain))SCOPe Domain Sequences for d2f5ah1:
Sequence; same for both SEQRES and ATOM records: (download)
>d2f5ah1 b.1.1.1 (H:1-132) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}
ritlkesgpplvkptqtltltcsfsgfslsdfgvgvgwirqppgkalewlaiiysdddkr
yspslntrltitkdtsknqvvlvmtrvspvdtatyfcahrrgpttlaaaaaaagpvnamd
vwgqgitvtiss
SCOPe Domain Coordinates for d2f5ah1:
Click to download the PDB-style file with coordinates for d2f5ah1.
(The format of our PDB-style files is described here.)
(The format of our PDB-style files is described here.)
Timeline for d2f5ah1:
- d2f5ah1 first appeared in SCOP 1.65
- d2f5ah1 appears in SCOPe 2.02
- d2f5ah1 appears in SCOPe 2.04
- d2f5ah1 appears in the current release, SCOPe 2.08
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