SCOPe 2.08: Domain d2cvza2: 2cvz A:2-157

Lineage for d2cvza2 (2cvz A:2-157)

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (19 proteins)
the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
C-terminal domains also show some similarity

Protein Hydroxyisobutyrate dehydrogenase [102171] (4 species)
Species Thermus thermophilus [TaxId:274] [102172] (2 PDB entries)
structural genomics
Domain d2cvza2: 2cvz A:2-157 [130891]
Other proteins in same PDB: d2cvza1, d2cvzb1, d2cvzc1, d2cvzd1
automatically matched to d1j3vc2
complexed with ndp

Details for d2cvza2

PDB Entry: 2cvz (more details), 1.8 Å

PDB Description: Structure of hydroxyisobutyrate dehydrogenase from thermus thermophilus HB8

PDB Compounds: (A:) 3-hydroxyisobutyrate dehydrogenase

SCOPe Domain Sequences for d2cvza2:

Sequence; same for both SEQRES and ATOM records: (download)

>d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}
ekvafiglgamgypmaghlarrfptlvwnrtfekalrhqeefgseavplervaearvift
clpttrevyevaealypylregtywvdatsgepeasrrlaerlrekgvtyldapvsggts
gaeagtltvmlggpeeavervrpflayakkvvhvgp

SCOPe Domain Coordinates for d2cvza2:

Click to download the PDB-style file with coordinates for d2cvza2.
(The format of our PDB-style files is described here.)

Timeline for d2cvza2: