Lineage for d1mxfa_ (1mxf A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2841004Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2841005Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2841375Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

    has additional subdomain(s) that are not in the common domain
  6. 2841754Protein Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
  7. 2841966Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  8. 2841971Domain d1mxfa_: 1mxf A: [91486]
    complexed with mtx, ndp

Details for d1mxfa_

PDB Entry: 1mxf (more details), 2.3 Å

PDB Description: crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi
PDB Compounds: (A:) pteridine reductase 2

SCOPe Domain Sequences for d1mxfa_:

Sequence, based on SEQRES records: (download)

>d1mxfa_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpgddtngaadakpidaqva
elfgsnavaplflirafarrqgeggawrsrnlsvvnlcdamtdlplpgfcvytmakhalg
gltraaalelaprhirvnavapglsllppampqetqeeyrrkvplgqseasaaqiadaia
flvskdagyitgttlkvdgglilara

Sequence, based on observed residues (ATOM records): (download)

>d1mxfa_ c.2.1.2 (A:) Dihydropteridin reductase (pteridine reductase) {Trypanosoma cruzi [TaxId: 5693]}
cpaavitggarrighsiavrlhqqgfrvvvhyrhsegaaqrlvaelnaaragsavlckgd
lslssslldccediidcsfrafgrcdvlvnnasayyptpllpkpidaqvaelfgsnavap
lflirafarrqnlsvvnlcdamtdlplpgfcvytmakhalggltraaalelaprhirvna
vapglsllppampqetqeeyrrkvplgqseasaaqiadaiaflvskdagyitgttlkvdg
glilara

SCOPe Domain Coordinates for d1mxfa_:

Click to download the PDB-style file with coordinates for d1mxfa_.
(The format of our PDB-style files is described here.)

Timeline for d1mxfa_: