Lineage for d1mvta_ (1mvt A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2903429Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2903430Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2903431Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2903757Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)
  7. 2903805Species Human (Homo sapiens) [TaxId:9606] [53607] (80 PDB entries)
  8. 2903874Domain d1mvta_: 1mvt A: [85157]
    complexed with dtm, so4

Details for d1mvta_

PDB Entry: 1mvt (more details), 1.8 Å

PDB Description: analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1mvta_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1mvta_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOPe Domain Coordinates for d1mvta_:

Click to download the PDB-style file with coordinates for d1mvta_.
(The format of our PDB-style files is described here.)

Timeline for d1mvta_: