Lineage for Family c.37.1.19: Tandem AAA-ATPase domain

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2865683Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2865684Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families) (S)
    division into families based on beta-sheet topologies
  5. 2870646Family c.37.1.19: Tandem AAA-ATPase domain [81268] (41 proteins)
    duplication: tandem repeat of two RecA-like (AAA) domains

Proteins:

  1. 2870647ATP-dependent RNA helicase DDX25 [142310] (1 species)
  2. 2870651CRISPR-associated protein Cas3 [419203] (1 species)
    second domain includes C-terminal linker region
  3. 2870677DEAD box RNA helicase rck/p54 [102387] (1 species)
  4. 2870681DEXX box DNA helicase [52701] (2 species)
    each AAA domain contains an all-alpha insert subdomain
    1. 2870682Species Bacillus stearothermophilus, PcrA [TaxId:1422] [52702] (5 PDB entries)
    2. 2870694Species Escherichia coli, RepD [TaxId:562] [52703] (1 PDB entry)
  5. 2870699DNA repair protein RAD25 [142318] (1 species)
    shares with the DNA helicase UvsW (102396) extra N-terminal alpha+beta subdomain that might be related to the DNA repair protein MutS domain I (55271)
  6. Exodeoxyribonuclease V alpha chain (RecD), C-terminal domain [418967] (1 species)
  7. 2870715Exodeoxyribonuclease V alpha chain (RecD), N-terminal domain [418966] (1 species)
    contains extra N-terminal alpha+beta (sub)domain (~100 residues)
  8. 2870719Exodeoxyribonuclease V beta chain (RecB), N-terminal domain [117550] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  9. 2870725Exodeoxyribonuclease V gamma chain (RecC), N-terminal domain [117552] (1 species)
    each AAA domain contains an all-alpha insert subdomain
  10. 2870731Hel308 helicase [159575] (1 species)
  11. 2870735Helicase of the SNF2/Rad54 hamily [142312] (1 species)
  12. 2870741Initiation factor 4a [52706] (2 species)
    homologous to UvrB
    1. 2870742Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52707] (4 PDB entries)
    2. 2870749Species Human (Homo sapiens) [TaxId:9606] [142305] (3 PDB entries)
      Uniprot P60842 21-238
      4A-I
  13. Nucleotide excision repair enzyme UvrB, C-terminal domain [418969] (2 species)
    1. Species Bacillus caldotenax [TaxId:1395] [419431] (4 PDB entries)
      Uniprot P56981
    2. Species Thermus thermophilus [TaxId:274] [419433] (2 PDB entries)
  14. 2870772Nucleotide excision repair enzyme UvrB, N-terminal domain [418968] (2 species)
    contains large insertions in the AAA domain
    1. 2870773Species Bacillus caldotenax [TaxId:1395] [419430] (4 PDB entries)
      Uniprot P56981
    2. 2870780Species Thermus thermophilus [TaxId:274] [419432] (2 PDB entries)
  15. 2870783Pre-mRNA splicing factor Cwf11 / Aquarius, C-terminal domain [419073] (2 species)
    1. 2870784Species Human (Homo sapiens) [TaxId:9606] [419565] (1 PDB entry)
    2. 2870786Species Schizosaccharomyces pombe 972h- [TaxId:284812] [419567] (1 PDB entry)
  16. 2870788Pre-mRNA splicing factor Cwf11 / Aquarius, N-terminal domain [419072] (2 species)
    this first domain includes 'stalk' (C-terminal part of Pfam PF16399), 'thumb' and 'pointer' insert subdomains described in PubMed 25599396
    1. 2870789Species Human (Homo sapiens) [TaxId:9606] [419564] (1 PDB entry)
    2. 2870791Species Schizosaccharomyces pombe 972h- [TaxId:284812] [419566] (1 PDB entry)
  17. 2870793Pre-mRNA splicing factor DEAH RNA helicase Prp43, C-terminal domain [419075] (1 species)
  18. 2870799Pre-mRNA splicing factor DEAH RNA helicase Prp43, N-terminal domain [419074] (1 species)
    this first domain contains extended N-terminal (sub)domain described in PubMed 20168331
  19. 2870805Probable ATP-dependent RNA helicase DDX48 [142314] (1 species)
    Eukaryotic translation initiation factor 4A isoform 3
  20. 2870815Probable DEAD box RNA helicase YqfR [102383] (1 species)
  21. Putative ATP-dependent RNA helicase DHH1, C-terminal domain [418971] (1 species)
  22. 2870822Putative ATP-dependent RNA helicase DHH1, N-terminal domain [418970] (1 species)
  23. 2870825putative ATP-dependent RNA helicase PF2015, C-terminal domain [419077] (1 species)
    separate structures of other domains are known: the middle nuclease domain (89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
  24. 2870833putative ATP-dependent RNA helicase PF2015, N-terminal domain [419076] (1 species)
    separate structures of other domains are known: the middle nuclease domain (89718) and the C-terminal RuvA-like HhH domain (PDB 1x2i)
  25. 2870841putative ATP-dependent RNA helicase VlgB [142306] (1 species)
  26. 2870844Putative DEAD box RNA helicase [52704] (1 species)
    homologous to eIF4a and UvrB
  27. 2870850Rad54-like, Rad54L [142316] (1 species)
  28. RecG helicase domain, C-terminal domain [418973] (1 species)
  29. 2870857RecG helicase domain, N-terminal domain [418972] (1 species)
  30. 2870860RecQ helicase domain [102385] (1 species)
  31. 2870866Retinoic acid-inducible gene I (RIG-I) helicase [419122] (1 species)
    Second structure includes C-terminal "bridging domain"
  32. 2870870Spliceosome RNA helicase BAT1 (UAP56) [110562] (1 species)
  33. 2870881Transcription-repair coupling factor TRCF, domain 1 [418974] (1 species)
    entire protein is similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  34. Transcription-repair coupling factor TRCF, domain 2 [418975] (1 species)
    entire protein is similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  35. Transcription-repair coupling factor TRCF, domain 3 [418976] (1 species)
    entire protein is similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  36. Transcription-repair coupling factor TRCF, domain 4 [418977] (1 species)
    entire protein is similar to UvrB in the N-terminal part and DEAD helicases in the C-terminal part; also contains CarD-like domain in the middle and TRCF domain at the C-terminus
  37. 2870899Translocation ATPase SecA, nucleotide-binding domains, C-terminal domain [418979] (3 species)
    1. Species Bacillus subtilis [TaxId:1423] [419443] (4 PDB entries)
      Uniprot P28366
    2. Species Mycobacterium tuberculosis [TaxId:1773] [419445] (2 PDB entries)
    3. 2870910Species Thermotoga maritima MSB8 [TaxId:243274] [419447] (1 PDB entry)
  38. 2870913Translocation ATPase SecA, nucleotide-binding domains, N-terminal domain [418978] (3 species)
    a pre-protein crosslinking domain inserted in this first AAA domain
    1. 2870914Species Bacillus subtilis [TaxId:1423] [419442] (4 PDB entries)
      Uniprot P28366
    2. 2870919Species Mycobacterium tuberculosis [TaxId:1773] [419444] (2 PDB entries)
    3. 2870924Species Thermotoga maritima MSB8 [TaxId:243274] [419446] (1 PDB entry)
  39. 2870927Upf1, C-terminal domain [419079] (1 species)
  40. 2870933Upf1, N-terminal domain [419078] (1 species)
    this first domain includes small helical insert subdomain
  41. 2870939automated matches [190301] (7 species)
    not a true protein
    1. 2870940Species Anas platyrhynchos [TaxId:8839] [419890] (1 PDB entry)
    2. 2870943Species Archaeoglobus fulgidus [TaxId:224325] [387738] (1 PDB entry)
    3. 2870946Species Escherichia coli K-12 [TaxId:83333] [232480] (1 PDB entry)
    4. 2870949Species Flatworm (Dugesia japonica) [TaxId:6161] [188089] (1 PDB entry)
    5. 2870951Species Human (Homo sapiens) [TaxId:9606] [187108] (5 PDB entries)
    6. Species Sulfolobus solfataricus [TaxId:2287] [267762] (1 PDB entry)
    7. 2870966Species Sulfolobus solfataricus [TaxId:273057] [267761] (1 PDB entry)

More info for Family c.37.1.19: Tandem AAA-ATPase domain

Timeline for Family c.37.1.19: Tandem AAA-ATPase domain: