PDB entry 7r6x

View 7r6x on RCSB PDB site
Description: SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2E12 Fab, S309 Fab, and S304 Fab
Class: viral protein/immune system
Keywords: COVID-19, SARS-CoV-2, neutralizing monoclonal antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2021-06-23, released 2021-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monoclonal antibody S309 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-229)
  • Chain 'B':
    Compound: Monoclonal antibody S309 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-213)
    Domains in SCOPe 2.08: d7r6xb_
  • Chain 'C':
    Compound: Monoclonal antibody S2E12 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-225)
    Domains in SCOPe 2.08: d7r6xc_
  • Chain 'D':
    Compound: Monoclonal antibody S2E12 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-215)
    Domains in SCOPe 2.08: d7r6xd_
  • Chain 'H':
    Compound: Monoclonal antibody S304 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-222)
    Domains in SCOPe 2.08: d7r6xh_
  • Chain 'L':
    Compound: Monoclonal antibody S304 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6X (0-214)
    Domains in SCOPe 2.08: d7r6xl_
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (4-207)
      • expression tag (0-3)
      • expression tag (208-215)
    Domains in SCOPe 2.08: d7r6xr_
  • Heterogens: NAG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7r6xB (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xB (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7r6xC (C:)
qvqlvqsgpevkkpgtsvrvsckasgftftssavqwvrqargqrlewvgwivvgsgntny
aqkfhervtitrdmststaymelsslrsedtavyycaspycsggscsdgfdiwgqgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xC (C:)
qvqlvqsgpevkkpgtsvrvsckasgftftssavqwvrqargqrlewvgwivvgsgntny
aqkfhervtitrdmststaymelsslrsedtavyycaspycsggscsdgfdiwgqgtmvt
vs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7r6xD (D:)
divltqtpgtlslspgeratlscrasqsvsssylawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqyvgltgwtfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xD (D:)
divltqtpscrasqsvsssylawyqqkpgqaprlliygassratgipdrfsgsgsgtdft
lyycqqyvgltgwtfgqg

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7r6xH (H:)
evqlvesggglvqpggslrlscaasgftfssydmhwvrqttgkglewvstigtagdtyyp
dsvkgrftisredaknslylqmnslragdtavyycargdssgyyyyfdywgqgtlltvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xH (H:)
vqlvesggglvqpggslrlscaasgftfssydmhwvrqttgkglewvstigtagdtyypd
svkgrftisredaknslylqmnslragdtavyycargdssgyyyyfdywgqgtlltvssa
stkgpsvfplaclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvcnvnhkp
sntkvd

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7r6xL (L:)
diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xL (L:)
diqmtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
psdeqlksgtasvvcllnnfypnsqesvteqdskdstyslsstl

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7r6xR (R:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6xR (R:)
pnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklnd
lcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggny
nylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyr
vvvlsfellhapatvcgpk