PDB entry 7lsg

View 7lsg on RCSB PDB site
Description: Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype)
Class: immune system/viral protein
Keywords: Tick-borne encephalitis virus, antibody, EDIII, TBEV, IMMUNE SYSTEM, IMMUNE SYSTEM-VIRAL PROTEIN complex
Deposited on 2021-02-18, released 2021-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: Core protein
    Species: Tick-borne encephalitis virus [TaxId:11084]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7lsgc_
  • Chain 'H':
    Compound: T025 Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LSG (0-End)
    Domains in SCOPe 2.08: d7lsgh_
  • Chain 'L':
    Compound: T025 Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LSG (0-End)
    Domains in SCOPe 2.08: d7lsgl1, d7lsgl2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7lsgC (C:)
gltytmcdktkfawkrtptdsghdtvvmevtfsgtkpcripvravahgfpdvnvamlitp
nptienngggfiemqlppgdniiyvgelshqwfqkgs

    Sequence, based on observed residues (ATOM records): (download) 
    >7lsgC (C:)
tytmcdktkfawkrtptdsghdtvvmevtfsgtkpcripvravahgfpdvnvamlitpnp
tienngggfiemqlppgdniiyvgelshqwfqkg

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7lsgH (H:)
qvqlvesgggvvqpgrslrlscaasgftfsnygmhwvrqapgkgldwvavisydaisksy
adsvegrftisrdnskntlylqmnslraedsavyycaksptaidppfdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lsgH (H:)
qvqlvesgggvvqpgrslrlscaasgftfsnygmhwvrqapgkgldwvavisydaisksy
adsvegrftisrdnskntlylqmnslraedsavyycaksptaidppfdywgqgtlvtvss
astkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7lsgL (L:)
eivmtqspatlsvspgeratlscwasqsvssnlawyqqkpgqaprlliygastratgipa
rfsasgsgteftltisslqsedfavyycqqynnwpprfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7lsgL (L:)
eivmtqspatlsvspgeratlscwasqsvssnlawyqqkpgqaprlliygastratgipa
rfsasgsgteftltisslqsedfavyycqqynnwpprfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg