PDB entry 7lju

View 7lju on RCSB PDB site
Description: Porcine Dihydropyrimidine Dehydrogenase (DPD) crosslinked with 5-Ethynyluracil (5EU)
Class: flavoprotein
Keywords: Dihydropyrimidine dehydrogenase, DPD, dehydrogenase, 5-Ethynyluracil, 5EU, inhibitor, inactivator, crosslinking, FLAVOPROTEIN
Deposited on 2021-01-30, released 2021-04-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-04-07, with a file datestamp of 2021-04-02.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.07: d7ljua1, d7ljua2, d7ljua3, d7ljua4, d7ljua5
  • Chain 'B':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.07: d7ljub1, d7ljub2, d7ljub3, d7ljub4, d7ljub5
  • Chain 'C':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.07: d7ljuc1, d7ljuc2, d7ljuc3, d7ljuc4, d7ljuc5
  • Chain 'D':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.07: d7ljud1, d7ljud2, d7ljud3, d7ljud4, d7ljud5
  • Heterogens: Y3G, FAD, FNR, NAP, SF4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7ljuA (A:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljuA (A:)
    apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
    ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
    lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
    mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
    nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
    gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
    vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
    dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
    ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
    finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
    pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
    adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
    raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
    aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
    sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
    aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
    tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7ljuB (B:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljuB (B:)
    pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
    khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
    gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
    peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
    feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
    fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
    frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
    edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
    vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
    inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
    gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
    dalelnlscacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeggadgvt
    atntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpgfpilat
    ggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelqgwdgqs
    pgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafpplerkpfi
    pkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiqf
    dpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >7ljuC (C:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljuC (C:)
    pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
    khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
    gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
    peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
    feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
    fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
    frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
    edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
    vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
    inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
    gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
    dalelnlscacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeggadgvt
    atntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpgfpilat
    ggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelqgwdgqs
    pgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafpplerkpfi
    pkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiqf
    dpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7ljuD (D:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljuD (D:)
    pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
    khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
    gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
    peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
    feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
    fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
    frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
    edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
    vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
    inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
    gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
    dalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiar
    aakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttia
    ralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylks
    ieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqna
    afpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymt
    cndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpl