PDB entry 7jx3

View 7jx3 on RCSB PDB site
Description: Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Class: viral protein/immune system
Keywords: COVID-19, SARS-CoV-2, neutralizing monoclonal antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2020-08-26, released 2020-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heavy chain of Fab domain of monoclonal antibody S309
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (0-End)
  • Chain 'B':
    Compound: Light chain of Fab domain of monoclonal antibody S309
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (0-End)
    Domains in SCOPe 2.08: d7jx3b1, d7jx3b2
  • Chain 'C':
    Compound: Heavy chain of Fab domain of monoclonal antibody S2H14
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (0-End)
    Domains in SCOPe 2.08: d7jx3c_
  • Chain 'D':
    Compound: Light chain of Fab domain of monoclonal antibody S2H14
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (0-End)
    Domains in SCOPe 2.08: d7jx3d1, d7jx3d2
  • Chain 'H':
    Compound: Heavy chain of Fab domain of monoclonal antibody S304
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (Start-222)
    Domains in SCOPe 2.08: d7jx3h_
  • Chain 'L':
    Compound: Light chain of Fab domain of monoclonal antibody S304
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JX3 (0-214)
    Domains in SCOPe 2.08: d7jx3l1, d7jx3l2
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7jx3r_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jx3B (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7jx3B (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7jx3C (C:)
evqlvesggglvkpggslrlscaasgftfsnawmswvrqapgkglewvgriksktdggtt
dyaapvkgrftisrddskntlylqmnslktedtavyycttgsetyyydssgpfdywgqgt
lvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7jx3C (C:)
evqlvesggglvkpggslrlscaasgftfsnawmswvrqapgkglewvgriksktdggtt
dyaapvkgrftisrddskntlylqmnslktedtavyycttgsetyyydssgpfdywgqgt
lvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7jx3D (D:)
nfmltqphsvsespgktvtisctrssgsiasnyvqwyqqrpgsspttviyednqrpsgvp
drfsgsidsssnsasltisglktedeadyycqsydssnqvfgggtkltvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7jx3D (D:)
nfmltqphsvsespgktvtisctrssgsiasnyvqwyqqrpgsspttviyednqrpsgvp
drfsgsidsssnsasltisglktedeadyycqsydssnqvfgggtkltvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvapt

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7jx3H (H:)
evqlvesggglvqpggslrlscaasgftfssydmhwvrqttgkglewvstigtagdtyyp
dsvkgrftisredaknslylqmnslragdtavyycargdssgyyyyfdywgqgtlltvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7jx3H (H:)
vqlvesggglvqpggslrlscaasgftfssydmhwvrqttgkglewvstigtagdtyypd
svkgrftisredaknslylqmnslragdtavyycargdssgyyyyfdywgqgtlltvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7jx3L (L:)
diemtqspsslsaavgdrvtitcrasqsigsylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfaiyycqqsyvsptytfgpgtkvdikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7jx3R (R:)
rfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptkl
ndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvgg
nynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqp
yrvvvlsfellhapatvcgpkkst

    Sequence, based on observed residues (ATOM records): (download) 
    >7jx3R (R:)
itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlc
ftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyny
lyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvv
vlsfellhapatvcgpkk