PDB entry 7jvm

View 7jvm on RCSB PDB site
Description: Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TNO155
Class: hydrolase/hydrolase inhibitor
Keywords: PHOSPHATASE PTP, INHIBITOR, PTPN11, ALLOSTERIC, SHP2, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2020-08-21, released 2020-09-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7jvma1, d7jvma2, d7jvma3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7jvmb1, d7jvmb2, d7jvmb3
  • Heterogens: VKS, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7jvmA (A:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >7jvmA (A:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkdvielkyplncadptserwfhghlsgkeaekll
tekgkhgsflvrespgdfvlsvrtgdskvthvmircqelkydvgggerfdsltdlvehyk
knpmvetlgtvlqlkqplnttrinaaeiesrvrelsklqgfweefetlqqqeckllysrk
egqrqenknknryknilpfdhtrvvlhdgdppvsdyinaniimpeksyiatqgclqntvn
dfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
elklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhc
sagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavq
hyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jvmB (B:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >7jvmB (B:)
rrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehhgqlkgdvielkyplncadptserwfhghlsgkeaekll
tekgkhgsflvrespgdfvlsvrtskvthvmircqelkydvgggerfdsltdlvehykkn
pmvetlgtvlqlkqplnttrinaaeiesrvrelskqgfweefetlqqqeckllysrkegq
rqenknknryknilpfdhtrvvlhvsdyinaniimppkksyiatqgclqntvndfwrmvf
qensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskv
gqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrt
gtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl