PDB entry 7jtg

View 7jtg on RCSB PDB site
Description: Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-43
Class: immune system/viral protein
Keywords: HCV, broadly neutralizing antibodies, bNAbs, E2 core, IGHV1-69, IMMUNE SYSTEM, IMMUNE SYSTEM-VIRAL PROTEIN complex
Deposited on 2020-08-17, released 2021-03-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-03-10, with a file datestamp of 2021-03-05.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RM11-43 Fab heavy chain
    Species: MACACA MULATTA [TaxId:9544]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JTG (0-End)
  • Chain 'B':
    Compound: RM11-43 Fab light chain
    Species: MACACA MULATTA [TaxId:9544]
    Database cross-references and differences (RAF-indexed):
    • PDB 7JTG (0-End)
    Domains in SCOPe 2.07: d7jtgb1, d7jtgb2
  • Chain 'E':
    Compound: Envelope glycoprotein E2
    Species: Recombinant Hepatitis C virus HK6a/JFH-1 [TaxId:595609]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jtgB (B:)
diqmtqspsslsasvgdkvtitchasqgisswlawyqqkpgkapkpliyaasslqsgvps
rfsgggsgadytltisslqpedfatyycqqyddlprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7jtgB (B:)
diqmtqspsslsasvgdkvtitchasqgisswlawyqqkpgkapkpliyaasslqsgvps
rfsgggsgadytltisslqpedfatyycqqyddlprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'E':
    No sequence available.