PDB entry 7ewb
View 7ewb on RCSB PDB site
Description: GDP-bound KRAS G12D in complex with TH-Z835
Class: hydrolase
Keywords: KRAS, G12D, Salt-bridge, Inhibitor, Complex, TH-Z835, HYDROLASE
Deposited on
2021-05-25, released
2021-12-29
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-12-29, with a file datestamp of
2021-12-24.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: N/A
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Isoform 2B of GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d7ewba1, d7ewba2 - Chain 'B':
Compound: Isoform 2B of GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d7ewbb1, d7ewbb2 - Chain 'C':
Compound: Isoform 2B of GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-169)
- expression tag (0)
- engineered mutation (12)
Domains in SCOPe 2.08: d7ewbc1, d7ewbc2 - Heterogens: 05I, GDP, GNP, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7ewbA (A:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>7ewbA (A:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
- Chain 'B':
Sequence, based on SEQRES records: (download)
>7ewbB (B:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>7ewbB (B:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke
- Chain 'C':
Sequence, based on SEQRES records: (download)
>7ewbC (C:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>7ewbC (C:)
gmteyklvvvgadgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke