PDB entry 7czd

View 7czd on RCSB PDB site
Description: Crystal structure of PD-L1 in complex with a VHH
Class: immune system
Keywords: antibody, Complex, VHH, IMMUNE SYSTEM
Deposited on 2020-09-08, released 2021-07-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: anti-PD-L1 VHH
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CZD (0-115)
    Domains in SCOPe 2.08: d7czda_
  • Chain 'B':
    Compound: Programmed cell death 1 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZQ7 (1-116)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7czdb1, d7czdb2
  • Chain 'C':
    Compound: anti-PD-L1 VHH
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7CZD (0-115)
    Domains in SCOPe 2.08: d7czdc_
  • Chain 'D':
    Compound: Programmed cell death 1 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZQ7 (1-116)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7czdd1, d7czdd2
  • Heterogens: EDO, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7czdA (A:)
evqlqesggglvqpggslrlscaasgftfssywmywlrqapgkglewvssinsdssstyy
rdsvkgrftisrdnakntlylqmnslksedtavyycakdpggyakgqgtqvtvssd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7czdB (B:)
mftvtvpkdlyvveygsnmtieckfpvekqldlaalivywemedkniiqfvhgeedlkvq
hssyrqrarllkdqlslgnaalqitdvklqdagvyrcmisyggadykritvkvnapy

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7czdC (C:)
evqlqesggglvqpggslrlscaasgftfssywmywlrqapgkglewvssinsdssstyy
rdsvkgrftisrdnakntlylqmnslksedtavyycakdpggyakgqgtqvtvssd

    Sequence, based on observed residues (ATOM records): (download) 
    >7czdC (C:)
evqlqesggglvqpggslrlscaasgftfssywmywlrqapgkglewvssinsdssstyy
rdsvkgrftisrdnakntlylqmnslksedtavyycakdpggyakgqgtqvtvs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7czdD (D:)
mftvtvpkdlyvveygsnmtieckfpvekqldlaalivywemedkniiqfvhgeedlkvq
hssyrqrarllkdqlslgnaalqitdvklqdagvyrcmisyggadykritvkvnapy