PDB entry 7b5q

View 7b5q on RCSB PDB site
Description: Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e)
Class: transcription
Keywords: Kinase, protein complex, small molecules inhibitor, CDK-activating kinase, TRANSCRIPTION
Deposited on 2020-12-05, released 2021-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: EM
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: cdk-activating kinase assembly factor mat1
    Species: Homo sapiens [TaxId:9606]
    Gene: MNAT1, CAP35, MAT1, RNF66
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Cyclin-H
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7b5qi1, d7b5qi2
  • Chain 'J':
    Compound: Cyclin-dependent kinase 7
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK7, CAK, CAK1, CDKN7, MO15, STK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7b5qj_
  • Heterogens: I74, HOH

PDB Chain Sequences:

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >7b5qI (I:)
myhnssqkrhwtfsseeqlarlradanrkfrckavangkvlpndpvflepheemtlckyy
ekrllefcsvfkpamprsvvgtacmyfkrfylnnsvmeyhpriimltcaflackvdefnv
sspqfvgnlresplgqekaleqileyellliqqlnfhlivhnpyrpfegflidlktrypi
lenpeilrktaddflnrialtdayllytpsqialtailssasragitmesylseslmlke
nrtclsqlldimksmrnlvkkyepprseevavlkqklerchsaelalnvitkkrkgyedd
dyvskkskheeeewtdddlvesl

    Sequence, based on observed residues (ATOM records): (download) 
    >7b5qI (I:)
myhnssqkrhwtfsseeqlarlradanrkfrckavangpndpvflepheemtlckyyekr
llefcsvfkpamprsvvgtacmyfkrfylnnsvmeyhpriimltcaflackvdefnvssp
qfvgnlresplgqekaleqileyellliqqlnfhlivhnpyrpfegflidlktrypilen
peilrktaddflnrialtdayllytpsqialtailssasragitmesylseslmlkenrt
clsqlldimksmrnlvkkyepprseevavlkqklerchsae

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >7b5qJ (J:)
maswshpqfekgggsgggsgggswshpqfeksgggsenlyfqsnamaldvksrakryekl
dflgegqfatvykardkntnqivaikkiklghrseakdginrtalreikllqelshpnii
glldafghksnislvfdfmetdleviikdnslvltpshikaymlmtlqgleylhqhwilh
rdlkpnnllldengvlkladfglaksfgspnraythqvvtrwyrapellfgarmygvgvd
mwavgcilaelllrvpflpgdsdldqltrifetlgtpteeqwpdmcslpdyvtfksfpgi
plhhifsaagddlldliqglflfnpcaritatqalkmkyfsnrpgptpgcqlprpncpve
tlkeqsnpalaikrkrtealeqgglpkklif

    Sequence, based on observed residues (ATOM records): (download) 
    >7b5qJ (J:)
kryekldflgegqfatvykardkntnqivaikkiklakdginrtalreikllqelshpni
iglldafghksnislvfdfmetdleviikdnslvltpshikaymlmtlqgleylhqhwil
hrdlkpnnllldengvlkladfglaksfgspnraythqvvtrwyrapellfgarmygvgv
dmwavgcilaelllrvpflpgdsdldqltrifetlgtpteeqwpdmcslpdyvtfksfpg
iplhhifsaagddlldliqglflfnpcaritatqalkmkyfsnrpgptpgcqlprpn