PDB entry 7b18

View 7b18 on RCSB PDB site
Description: SARS-CoV-spike bound to two neutralising nanobodies
Class: viral protein
Keywords: spike glycoprotein, SARS-CoV-2, nanobody, VIRAL PROTEIN
Deposited on 2020-11-24, released 2021-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: EM
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • conflict (985-986)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • conflict (985-986)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • conflict (985-986)
  • Chain 'D':
    Compound: Nanobody against SARS-CoV-2 VHH E
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (Start-129)
    Domains in SCOPe 2.08: d7b18d_
  • Chain 'E':
    Compound: Nanobody against spike glycoprotein VHH V
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (0-120)
    Domains in SCOPe 2.08: d7b18e_
  • Chain 'F':
    Compound: Nanobody against SARS-CoV-2 VHH E
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (Start-129)
    Domains in SCOPe 2.08: d7b18f_
  • Chain 'G':
    Compound: Nanobody against spike glycoprotein VHH V
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (0-120)
    Domains in SCOPe 2.08: d7b18g_
  • Chain 'H':
    Compound: Nanobody against SARS-CoV-2 VHH E
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (Start-129)
    Domains in SCOPe 2.08: d7b18h_
  • Chain 'I':
    Compound: Nanobody against spike glycoprotein VHH V
    Species: Vicugna pacos [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 7B18 (0-120)
    Domains in SCOPe 2.08: d7b18i_
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7b18D (D:)
    sqvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrty
    ysdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdyw
    gkgtqvtvss
    

    Sequence, based on observed residues (ATOM records): (download)
    >7b18D (D:)
    qvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrtyy
    sdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdywg
    kgtqvtvss
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >7b18E (E:)
    qvqlvetggglvqpggslrlscaasgftfssyamgwarqvpgkglewvsyiysdgsteyq
    dsvkgrftisrdnakstvylqmnslkpedtavyycategslggwgrdfgswgqgtqvtvs
    s
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >7b18F (F:)
    sqvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrty
    ysdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdyw
    gkgtqvtvss
    

    Sequence, based on observed residues (ATOM records): (download)
    >7b18F (F:)
    qvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrtyy
    sdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdywg
    kgtqvtvss
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >7b18G (G:)
    qvqlvetggglvqpggslrlscaasgftfssyamgwarqvpgkglewvsyiysdgsteyq
    dsvkgrftisrdnakstvylqmnslkpedtavyycategslggwgrdfgswgqgtqvtvs
    s
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >7b18H (H:)
    sqvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrty
    ysdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdyw
    gkgtqvtvss
    

    Sequence, based on observed residues (ATOM records): (download)
    >7b18H (H:)
    qvqlvetgggfvqpggslrlscaasgvtldyyaigwfrqapgkeregvscigssdgrtyy
    sdsvkgrftisrdnakntvylqmnslkpedtavyycaltvgtyysgnyhytcsddmdywg
    kgtqvtvss
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >7b18I (I:)
    qvqlvetggglvqpggslrlscaasgftfssyamgwarqvpgkglewvsyiysdgsteyq
    dsvkgrftisrdnakstvylqmnslkpedtavyycategslggwgrdfgswgqgtqvtvs
    s