PDB entry 7auv
View 7auv on RCSB PDB site
Description: The structure of ERK2 in complex with dual inhibitor ASTX029
Class: signaling protein
Keywords: Mitogen activated kinase ATP binding Protein phosphorylation Serine/threonine protein kinase, SIGNALING PROTEIN
Deposited on
2020-11-03, released
2021-10-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-10-13, with a file datestamp of
2021-10-08.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mitogen-activated protein kinase 1
Species: Homo sapiens [TaxId:9606]
Gene: MAPK1, ERK2, PRKM1, PRKM2
Database cross-references and differences (RAF-indexed):
- Uniprot P28482 (8-367)
- initiating methionine (0)
- expression tag (1-7)
Domains in SCOPe 2.08: d7auva_ - Heterogens: RYW, SO4, DMS, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7auvA (A:)
mahhhhhhmaaaaaagagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrva
ikkispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdl
ykllktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglar
vadpdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkh
yldqlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldk
mltfnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeeta
rfqpgyrs
Sequence, based on observed residues (ATOM records): (download)
>7auvA (A:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg