PDB entry 6xy2

View 6xy2 on RCSB PDB site
Description: Crystal structure of CTLA-4 complexed with the Fab of HL32 antibody
Class: immune system
Keywords: CTLA-4, Fab, antibody, immunnotherapy, IMMUNE SYSTEM
Deposited on 2020-01-29, released 2020-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytotoxic t-lymphocyte protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: CTLA4, CD152
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6xy2a_
  • Chain 'H':
    Compound: heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XY2
  • Chain 'L':
    Compound: light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XY2 (0-End)
    Domains in SCOPe 2.08: d6xy2l1, d6xy2l2
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xy2A (A:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidpepc
pds

    Sequence, based on observed residues (ATOM records): (download) 
    >6xy2A (A:)
mhvaqpavvlassrgiasfvceyaspgkatevrvtvlrqadsqvtevcaatymmgneltf
lddsictgtssgnqvnltiqglramdtglyickvelmypppyylgigngtqiyvidp

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6xy2L (L:)
diqmtqspsslsasvgdrvtitcraseniysnlawyqqkqgkapklllyaatnlqdgvps
rfsgsgsgtdytltisslqpedfatyfcqhlwgtpytfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6xy2L (L:)
diqmtqspsslsasvgdrvtitcraseniysnlawyqqkqgkapklllyaatnlqdgvps
rfsgsgsgtdytltisslqpedfatyfcqhlwgtpytfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg