PDB entry 6x4t

View 6x4t on RCSB PDB site
Description: Crystal structure of ICOS-L in complex with Prezalumab and VNAR domain
Class: immune system
Keywords: Immune checkpoint, immune system, receptor ligand, glycoprotein, antibody, B cell
Deposited on 2020-05-23, released 2020-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-21, with a file datestamp of 2020-10-16.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ICOS ligand
    Species: Homo sapiens [TaxId:9606]
    Gene: ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75144 (2-End)
      • cloning artifact (1)
  • Chain 'B':
    Compound: Prezalumab Fab Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T (0-End)
    Domains in SCOPe 2.08: d6x4tb_
  • Chain 'C':
    Compound: ICOS ligand
    Species: Homo sapiens [TaxId:9606]
    Gene: ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Prezalumab Fab Heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T (0-End)
    Domains in SCOPe 2.08: d6x4td_
  • Chain 'E':
    Compound: Prezalumab Fab Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T (0-End)
    Domains in SCOPe 2.08: d6x4te1, d6x4te2
  • Chain 'F':
    Compound: Prezalumab Fab Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T (0-End)
    Domains in SCOPe 2.08: d6x4tf1, d6x4tf2
  • Chain 'G':
    Compound: vnar
    Species: Orectolobus maculatus [TaxId:168098]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T
    Domains in SCOPe 2.08: d6x4tg_
  • Chain 'N':
    Compound: vnar
    Species: Orectolobus maculatus [TaxId:168098]
    Database cross-references and differences (RAF-indexed):
    • PDB 6X4T
    Domains in SCOPe 2.08: d6x4tn_
  • Heterogens: NAG, GOL

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6x4tB (B:)
evqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvayikqdgnekyy
vdsvkgrftisrdnaknslylqmnslraedtavyycaregilwfgdlptfwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6x4tD (D:)
evqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvayikqdgnekyy
vdsvkgrftisrdnaknslylqmnslraedtavyycaregilwfgdlptfwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6x4tD (D:)
evqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvayikqdgnekyy
vdsvkgrftisrdnaknslylqmnslraedtavyycaregilwfgdlptfwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6x4tE (E:)
diqmtqspsslsasvgdrvtitcrasqgisnwlawyqqkpekapksliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqydsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6x4tE (E:)
diqmtqspsslsasvgdrvtitcrasqgisnwlawyqqkpekapksliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqydsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6x4tF (F:)
diqmtqspsslsasvgdrvtitcrasqgisnwlawyqqkpekapksliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqydsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6x4tF (F:)
diqmtqspsslsasvgdrvtitcrasqgisnwlawyqqkpekapksliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqydsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6x4tG (G:)
tgarvdqtprsvtketgesltincvlrdpsyalgstcwyrkksgstneesiskggryvet
vnsgsksfslrindltvedggtyrcgatdtvriyscdylcalnghrdaacgggtvvtvng
gswshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6x4tG (G:)
garvdqtprsvtketgesltincvlrdpsyalgstcwyrkksgstneesiskggryvetv
nsgsksfslrindltvedggtyrcgatdtvriyscdylcalnghrdaacgggtvvtvn

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6x4tN (N:)
tgarvdqtprsvtketgesltincvlrdpsyalgstcwyrkksgstneesiskggryvet
vnsgsksfslrindltvedggtyrcgatdtvriyscdylcalnghrdaacgggtvvtvng
gswshpqfek

    Sequence, based on observed residues (ATOM records): (download) 
    >6x4tN (N:)
garvdqtprsvttincvlrdpsyalgstcwyrkksgstneesiskyvetvnsgsksfslr
indltvedggtyrcgatdtvriyscdylcalnghrdaacgggtvv